We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protective Effects of Velvet Antler Methanol Extracts on Hypoxia-Induced Damage in Caenorhabditis elegans through HIF-1 and ECH-8 Mediated Lipid Accumulation.
- Authors
Li, Ru; Li, Hongyuan; Wang, Xiaohui; Peng, Yinghua
- Abstract
Velvet antler, a traditional tonic widely used in East Asia for its health benefits, is explored in this study for its protective effects against hypoxia-induced damage using Caenorhabditis elegans (C. elegans) as a model. Hypoxia, characterized by low oxygen availability, induces significant physiological stress and potential tissue damage. Our research demonstrates that methanol extracts from velvet antler (MEs) enhance the survival of C. elegans under hypoxic conditions. This enhancement is achieved through the stabilization of hypoxia-inducible factor-1 (HIF-1) and the promotion of lipid accumulation, both of which are crucial for mitigating cellular damage. Specifically, MEs improve mitochondrial function, increase ATP production, and aid in the recovery of physical activity in C. elegans post-hypoxia or following hypoxia–reoxygenation (HR). The pivotal role of HIF-1 is underscored by the loss of these protective effects when HIF-1 function is inhibited. Additionally, our findings reveal that the gene related to lipid metabolism, ech-8, significantly contributes to the lipid accumulation that enhances resilience to hypoxia in C. elegans treated with MEs. These results not only highlight the therapeutic potential of velvet antler in modern medical applications, particularly for conditions involving hypoxic stress, but also provide insights into the molecular mechanisms by which MEs confer protection against hypoxic damage.
- Subjects
MITOCHONDRIAL physiology; LIPID metabolism; BIOLOGICAL models; RESEARCH funding; MITOCHONDRIA; LIPIDS; TRANSCRIPTION factors; GENE expression; MAMMALS; ASIAN medicine; ANIMAL experimentation; METHANOL; CONVALESCENCE; TISSUE extracts; PHYSIOLOGICAL stress; CAENORHABDITIS elegans; HYPOXEMIA; PHYSICAL activity; DISEASE complications
- Publication
Nutrients, 2024, Vol 16, Issue 14, p2257
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16142257