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- Title
Impact of Chemotherapy Regimens on Body Composition of Breast Cancer Women: A Multicenter Study across Four Brazilian Regions.
- Authors
Godinho-Mota, Jordana Carolina Marques; Vaz-Gonçalves, Larissa; Dias Custódio, Isis Danyelle; Schroeder de Souza, Jaqueline; Mota, João Felipe; Gonzalez, Maria Cristina; Rodrigues Vilella, Priscylla; Anusca Martins, Karine; Paiva Maia, Yara Cristina de; Verde, Sara Maria Moreira Lima; Frenzel, Aline Porciúncula; Di Pietro, Patricia Faria; Costa Marinho, Eduarda da; Freitas-Junior, Ruffo
- Abstract
This study aimed to investigate the effect of chemotherapy (CT) and its different types of regimens on the anthropometry and body composition of women with breast cancer. Three-hundred-and-four women with breast cancer were enrolled in this multicenter study. The participants were evaluated before the infusion of the first cycle of CT (pre-CT), and until two weeks after CT completion (post-CT), regarding body weight, body mass index (BMI); waist circumference (WC); waist-to-height ratio (WHtR); conicity index (C-index); fat mass index (FMI); and fat-free mass index (FFMI). CT regimens were classified as anthracycline-based (AC—doxorubicin or epirubicin); anthracyclines and taxane (ACT); cyclophosphamide, methotrexate, and 5-fluorouracil (CMF); or isolated taxanes (paclitaxel or docetaxel). Women significantly increased BMI and FMI post-CT (p < 0.001 and p = 0.007, respectively). The ACT regimen increased FMI (p < 0.001), while FFMI increased after AC (p = 0.007). It is concluded that the CT negatively impacted body composition and the type of regime had a strong influence. The ACT regimen promoted an increase in FMI compared to other regimens, and the AC increased FFMI. These findings reinforce the importance of nutritional monitoring of breast cancer patients throughout the entire CT treatment.
- Subjects
BRAZIL; WOMEN -- Brazil; BODY composition; RESEARCH; CONFIDENCE intervals; CANCER chemotherapy; ANTHROPOMETRY; RETROSPECTIVE studies; CANCER patients; SOCIOECONOMIC factors; RESEARCH funding; DESCRIPTIVE statistics; DATA analysis software; BREAST tumors; SECONDARY analysis
- Publication
Nutrients, 2023, Vol 15, Issue 7, p1689
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15071689