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- Title
Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine.
- Authors
Kim, Duhyeon; Kim, Seonghui; Yoon, Minseok; Um, Min Young; Cho, Suengmok
- Abstract
Wakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly consumed through coffee. Although green tea (Camellia sinensis L.) contains high caffeine content like coffee, its arousal-inducing effects have not yet been studied. In the present study, we aimed to identify the arousal-inducing effect of GT during a chronic administration period (three weeks) using analysis of sleep architecture. Treatment with GT (1500 mg/kg) significantly elevated the sleep latency and wakefulness throughout the treatment period, and chronic administration of GT consistently maintained an increase in wakefulness for up to 3 h. During the treatment period, the arousal-inducing effect of GT (1500 mg/kg) occurred without any change in the tolerance phenomenon or withdrawal symptoms, similar to that observed with caffeine (25 mg/kg). GT (1500 mg/kg) containing 95.6 mg/kg of caffeine did not produce a better arousal-inducing effect than caffeine at 25 mg/kg. These results indicate that the arousal-inducing effect of GT persisted for three weeks without adverse effects and that GT can control the arousal-inducing effects of caffeine due to the hypnotic effects of its other constituents.
- Subjects
AROUSAL (Physiology); ELECTROENCEPHALOGRAPHY; ANALYSIS of variance; ANIMAL experimentation; POLYSOMNOGRAPHY; GREEN tea; SLEEP; T-test (Statistics); COMPARATIVE studies; DESCRIPTIVE statistics; ETHANOL; PLANT extracts; DATA analysis software; ELECTROMYOGRAPHY; MICE
- Publication
Nutrients, 2023, Vol 15, Issue 4, p1042
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15041042