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- Title
Dietary Factors May Delay Tolerance Acquisition in Food Protein-Induced Allergic Proctocolitis.
- Authors
Feketea, Gavriela; Lakoumentas, John; Konstantinou, George N.; Douladiris, Nikolaos; Papadopoulos, Nikolaos G.; Petrodimopoulou, Maria; Tasios, Ioannis; Valianatou, Mina; Vourga, Vasiliki; Vassilopoulou, Emilia
- Abstract
Background: Dietary and environmental factors may influence tolerance acquisition in food protein-induced allergic proctocolitis (FPIAP). This retrospective observational study explored the role of maternal diet during pregnancy and breastfeeding in tolerance acquisition in infantile FPIAP. Methods: Breastfed infants with FPIAP from six diverse regions in Greece were divided into two groups, based on development of tolerance to the trigger food: Group A (n = 43), before, and Group B (n = 53), after, the 6th month of age. Maternal diet during pregnancy and breastfeeding was elicited using the Mediterranean Diet Score Questionnaire and the Mediterranean Oriented Culture Specific Semi-Quantitative Food Frequency Questionnaire. Results: Mean age at diagnosis of FPIAP (1.5 months) and weaning (5.5 months) were the same in both groups. The main trigger was cow's milk. Group A received infant milk formula earlier than Group B. Group B had a higher incidence of asthma/wheeze, siblings with milk allergy, maternal smoking and rural residence. On multivariate analysis, earlier resolution of FPIAP was associated with higher maternal education and with salt intake and consumption of goat/sheep cheese during pregnancy and olive oil during breastfeeding. Consumption of multivitamins during pregnancy and meat, winter fruits, green vegetables, butter, salt, "ready-to-eat" meals and pastries during breastfeeding were correlated with longer duration of symptoms. Conclusions: Mothers of children with FPIAP to cow's milk protein can be advised to eat more yogurt, cheese and olive oil during subsequent pregnancies, and avoid multivitamins, grilled food, "ready-to-eat" meals, pastries, meat and alcohol during breastfeeding, to reduce the duration of FPIAP presenting in future infants.
- Subjects
GREECE; ULCERATIVE colitis; MILK allergy; INFANT formulas; OLIVE oil; VITAMINS; LACTATION; YOGURT; RESEARCH; ASTHMA; CHEESE; MEAT; VEGETABLES; BUTTER; CONVENIENCE foods; FOOD intolerance; RURAL conditions; MULTIVARIATE analysis; SELF-evaluation; DIET; RETROSPECTIVE studies; DISEASE incidence; MANN Whitney U Test; RISK assessment; RESPIRATORY organ sounds; BREASTFEEDING; DESCRIPTIVE statistics; FRUIT; QUESTIONNAIRES; CHI-squared test; STATISTICAL hypothesis testing; SMOKING; RESIDENTIAL patterns; RECEIVER operating characteristic curves; STATISTICAL models; DATA analysis software; DIETARY proteins; FOOD allergy; EDUCATIONAL attainment; DIETARY sodium; PREGNANCY; DISEASE risk factors; CHILDREN
- Publication
Nutrients, 2023, Vol 15, Issue 2, p425
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15020425