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- Title
Can Bioactive Food Substances Contribute to Cystic Fibrosis-Related Cardiovascular Disease Prevention?
- Authors
Trandafir, Laura Mihaela; Frăsinariu, Otilia Elena; Țarcă, Elena; Butnariu, Lăcrămioara Ionela; Leon Constantin, Maria Magdalena; Moscalu, Mihaela; Temneanu, Oana Raluca; Melinte Popescu, Alina Sinziana; Popescu, Marian George Melinte; Stârcea, Iuliana Magdalena; Cojocaru, Elena; Moisa, Stefana Maria
- Abstract
Advances in cystic fibrosis (CF) care have significantly improved the quality of life and life expectancy of patients. Nutritional therapy based on a high-calorie, high-fat diet, antibiotics, as well as new therapies focused on CFTR modulators change the natural course of the disease. They do so by improving pulmonary function and growing BMI. However, the increased weight of such patients can lead to unwanted long-term cardiovascular effects. People with CF (pwCF) experience several cardiovascular risk factors. Such factors include a high-fat diet and increased dietary intake, altered lipid metabolism, a decrease in the level of fat-soluble antioxidants, heightened systemic inflammation, therapeutic interventions, and diabetes mellitus. PwCF must pay special attention to food and eating habits in order to maintain a nutritional status that is as close as possible to the proper physiological one. They also have to benefit from appropriate nutritional counseling, which is essential in the evolution and prognosis of the disease. Growing evidence collected in the last years shows that many bioactive food components, such as phytochemicals, polyunsaturated fatty acids, and antioxidants have favorable effects in the management of CF. An important positive effect is cardiovascular prevention. The possibility of preventing/reducing cardiovascular risk in CF patients enhances both quality of life and life expectancy in the long run.
- Subjects
CARDIOVASCULAR disease prevention; CARDIOVASCULAR diseases risk factors; UNSATURATED fatty acids; FOOD consumption; LIFE expectancy; ORGANIC compounds; ANTIOXIDANTS; CYSTIC fibrosis; PHYTOCHEMICALS; FOOD; QUALITY of life; BODY mass index; DIETARY fats; DISEASE complications
- Publication
Nutrients, 2023, Vol 15, Issue 2, p314
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15020314