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- Title
Polyphenol-Rich Liupao Tea Extract Prevents High-Fat Diet-Induced MAFLD by Modulating the Gut Microbiota.
- Authors
Tang, Waijiao; Yuan, Mengfei; Li, Zewen; Lin, Qi; Zhen, Yan; Li, Zhuang; Zhou, Hongwei; Xia, Fangbo
- Abstract
The modulation of gut microbiota dysbiosis might regulate the progression of metabolic-associated fatty liver disease (MAFLD). Here, we found that polyphenol-rich Liupao tea extract (PLE) prevents high-fat diet (HFD)-induced MAFLD in ApoE−/− male mice accompanied by protection of the intestinal barrier and downregulation of lipopolysaccharide (LPS)-related Toll-like receptor 4 (TLR4)-myeloid differentiation primary response 88 (MyD88) signaling in the liver. Fecal microbiome transplantation (FMT) from PLE-and-HFD-treated mice delayed MAFLD development significantly compared with FMT from HFD-treated mice. In this case, 16S rRNA gene sequencing revealed that Rikenellaceae and Odoribacter were significantly enriched and that Helicobacter was significantly decreased in not only the HFD+PLE group but also the HFD+PLE-FMT group. Furthermore, the level of 3-sulfodeoxycholic acid was significantly decreased in the HFD+PLE-FMT group compared with the HFD-FMT group. In conclusion, our data demonstrate that PLE could modulate the MAFLD phenotype in mice and that this effect is partly mediated through modulation of the gut microbiota.
- Subjects
LIPOPOLYSACCHARIDES; POLYPHENOLS; MEDICINAL plants; SEQUENCE analysis; GUT microbiome; LIVER; ANIMAL experimentation; NON-alcoholic fatty liver disease; RNA; HELICOBACTER; METABOLIC disorders; CELLULAR signal transduction; COMPARATIVE studies; BILE acids; TEA; PLANT extracts; FECAL microbiota transplantation; DIETARY fats; TOLL-like receptors; CARRIER proteins; MICE; DISEASE complications
- Publication
Nutrients, 2022, Vol 14, Issue 22, p4930
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14224930