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- Title
The Interactive Effects of Severe Vitamin D Deficiency and Iodine Nutrition Status on the Risk of Thyroid Disorder in Pregnant Women.
- Authors
Lu, Wei; Wang, Zhengyuan; Sun, Zhuo; Shi, Zehuan; Song, Qi; Cui, Xueying; Shen, Liping; Qu, Mengying; Mai, Shupeng; Zang, Jiajie
- Abstract
Thyroid dysfunction is associated with both vitamin D deficiency and iodine; however, it is unclear whether they interact. This study aimed to investigate whether and to what extent the interactions between vitamin D and iodine contribute to the risk of thyroid disorder. Participants (n = 4280) were chosen using multistage, stratified random sampling from Shanghai. Fasting blood was drawn for the 25(OH)D and thyroid parameter tests. Spot urine samples were gathered to test for urine iodine. To evaluate the interactive effects of vitamin D and iodine, crossover analysis was carried out. Pregnant women with a high urinary iodine concentration (UIC) and severe vitamin D deficiency had a significantly higher risk of thyrotropin receptor antibody (TrAb) positivity (odds ratio = 2.62, 95% confidence interval (CI): 1.32, 5.22) in the first trimester. Severe vitamin D deficiency and high UIC interacted positively for the risk of TrAb positivity (relative excess risk due to interaction = 1.910, 95%CI: 0.054, 3.766; attributable proportion = 0.700, 95%CI: 0.367, 1.03). Severe vitamin D deficiency combined with excess iodine could increase the risk of TrAb positivity in pregnant women in the first trimester.
- Subjects
CHINA; FASTING; THYROID gland function tests; THYROTROPIN; THYROID diseases; CONFIDENCE intervals; FIRST trimester of pregnancy; PREGNANT women; SEVERITY of illness index; RISK assessment; VITAMIN D; DESCRIPTIVE statistics; VITAMIN D deficiency; STATISTICAL sampling; CROSSOVER trials; ODDS ratio; IODINE; NUTRITIONAL status; WOMEN'S health; DISEASE risk factors; DISEASE complications; PREGNANCY
- Publication
Nutrients, 2022, Vol 14, Issue 21, p4484
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14214484