We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies.
- Authors
Canaan, Marcelo M.; Reis-Canaan, Juliana C.; Zangerônimo, Márcio G.; Andrade, Eric F.; Gonçalves, Thais M. S. V.; Pereira, Michel C. A.; Lima, Renato R.; Pardi, Vanessa; Murata, Ramiro M.; Pereira, Luciano J.
- Abstract
Dietary fiber supplementation has been studied as a promising strategy in the treatment of obesity and its comorbidities. A systematic review and meta-analysis were performed to verify whether the consumption of yeast beta-glucan (BG) favors weight loss in obese and non-obese rodents. The PICO strategy was employed, investigating rodents (Population), subjected to the oral administration of yeast BG (Intervention) compared to animals receiving placebo (Comparison), evaluating body weight changes (Outcome), and based on preclinical studies (Study design). Two reviewers searched six databases and the grey literature. We followed the PRISMA 2020 guidelines, and the protocol was registered on PROSPERO (CRD42021267788). The search returned 2467 articles. Thirty articles were selected for full-text evaluation, and seven studies remained based on the eligibility criteria. The effects of BG intake on body weight were analyzed based on obese (n = 4 studies) and non-obese animals (n = 4 studies). Even though most studies on obese rodents (75%) indicated a reduction in body weight (qualitative analysis), the meta-analysis showed this was not significant (mean difference −1.35 g—95% CI −5.14:2.45). No effects were also observed for non-obese animals. We concluded that the ingestion of yeast BG barely affects the body weight of obese and non-obese animals.
- Subjects
REDUCING diets; REGULATION of body weight; RODENTS; ONLINE information services; BODY weight; MEDICAL information storage &; retrieval systems; CONFIDENCE intervals; META-analysis; GLUCANS; SYSTEMATIC reviews; YEAST; PLACEBOS; TREATMENT effectiveness; DESCRIPTIVE statistics; MEDLINE; ODDS ratio
- Publication
Nutrients, 2021, Vol 13, Issue 12, p4250
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13124250