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- Title
Characteristics and Glucose Uptake Promoting Effect of Chrysin-Loaded Phytosomes Prepared with Different Phospholipid Matrices.
- Authors
Kim, Seong-Min; Jung, Jae-In; Chai, Changhoon; Imm, Jee-Young
- Abstract
Chrysin-loaded phytosomes (CP) were prepared using either soya phosphatidylcholine (SPC) or egg phospholipid (EPL) by the solvent evaporation method. Different phospholipid matrices resulted in significant differences in size, mechanical property and solubility of the CP. The most stable CP was obtained with EPL at a molar ratio of 1:3 (chrysin: EPL, CEP-1:3). CEP-1:3 displayed an average size of 117 nm with uniform size distribution (polydispersity index: 0.30) and zeta potential of −31 mV. A significantly greater elastic modulus of CEP-1:3 (2.7-fold) indicated tighter packing and strong molecular bonding than those of CP prepared with SPC (CSP-1:3). X-ray diffraction and Fourier transform infrared spectroscopic analysis of CEP-1:3 confirmed molecular complexation. CEP-1:3 displayed a greater glucose uptake promoting effect than free chrysin and CSP-1:3 in muscle cells by stimulating gene expression of peroxisome proliferator-activated receptor γ and glucose transporter type 4. The results of the present study suggest that the phospholipid matrix used for the preparation of phytosomes critically influences their performance.
- Subjects
EGGS; BLOOD sugar; GENE expression; INFRARED spectroscopy; LECITHIN; PHOSPHOLIPIDS; SOLUBILITY; SOYBEAN; X-rays; PEROXISOME proliferator-activated receptors; FLAVONES
- Publication
Nutrients, 2019, Vol 11, Issue 10, p2549
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11102549