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- Title
Tetratricopeptide repeat domain 9A knockout induces social anxiety and impairs offense behaviors in female mice.
- Authors
Wing Shan Yu; Li Guan; Shawn Zheng Kai Tan; Shrestha, Smeeta; Yu Zuan Or; Lufkin, Thomas; Lin, Valerie C. L.; Lee Wei Lim
- Abstract
Objective(s): The involvement of tetratricopeptide repeat domain 9A (TTC9A) in anxiety-like behaviors through estrogen action has been reported in female mice, this study further investigated its effects on social anxiety and aggressive behaviors. Materials and Methods: Using female Ttc9a knockout (Ttc9a-/-) mice, the role of TTC9A in anxiety was investigated in non-social and social environments through home-cage emergence and social interaction tests, respectively, whereas aggressive behaviors were examined under the female intruder test. Results: We observed significant social behavioral deficits with pronounced social and non-social anxiogenic phenotypes in female Ttc9a-/-mice. When tested for aggressive-like behaviors, we found a reduction in offense in Ttc9a-/-animals, suggesting that TTC9A deficiency impairs the offense responses in female mice. Conclusion: Future study investigating mechanisms underlying the social anxiety-like behavioral changes in Ttc9a-/-mice may promote the understanding of social and anxiety disorders.
- Subjects
SOCIAL anxiety; ANXIETY disorders; AGGRESSION (Psychology); MICE; FEMALES; ANXIETY
- Publication
Iranian Journal of Basic Medical Sciences, 2022, Vol 25, Issue 6, p398
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/IJBMS.2022.63044.13932