We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Single dose oral vitamin D3 90,000 IU is safe and as effective as 300,000 IU in treatment of nutritional rickets in children.
- Authors
Mittal, Medha; Yadav, Vineeta; Khadgawat, Rajesh; Kumar, Manish; Sherwani, Poonam
- Abstract
Aim: To compare efficacy and safety of 90,000IU and 3,00,000 IU oral single dose vitamin D3 for treatment of nutritional rickets in children. Materials and Methods: Study design-Randomized Controlled Trial. Setting: Tertiary care hospital. Participants--110 children (6 months to 5 years, median age 10.5 months), with radiological and biochemical diagnosis of rickets. Exclusion criteria were- confirmed/suspected diagnosis of malabsorption, severe systemic illness, intake of calcium/vitamin D preparation in last 6 months and rickets other than nutritional. Intervention: Vitamin D3 as a single oral dose 90,000 IU (group A, n = 55) or 3,00,000 IU (group B, n = 55). Methodology: Severity of rickets was scored on knee and wrist x-ray as per Thatcher's radiographic score. Baseline serum levels of calcium, ALP, 25(OH)D, PTH were measured. Follow up was done at 1 week, 1 month and 3 months. Outcome variable--Primary- Radiolographic score at 3 months. Secondary-serum levels of 25(OH)D, ALP and PTH at 3 months, clinical and biochemical adverse effects. Results: 86 patients (43 in each group) completed the 3 months' follow up. The baseline mean radiolographic score was 6.90 in group A and 6.93 in group B. It reduced to 0.16 in group A and 0.23 in group B at 3 months. The two groups had comparable median serum levels of 25(OH)D, ALP and PTH at baseline and at 3 months. In each group, 25(OH)D increased and ALP and PTH decreased significantly from the baseline. There was no case of hypercalciuria. At 1 month there were 5 cases of hypercalcemia (Group A-3, group B-2) and at 3 months-3 in each group. There were 2 cases of hypervitaminosis (serum 25(OH) D >150ng/mL) in group B. There were no clinical adverse events. Conclusion: Single oral dose vitamin D3 90,000 IU is safe and as effective as 300,000 IU in achieving healing of rickets.
- Subjects
RICKETS treatment; VITAMIN D deficiency; DRUG side effects
- Publication
Indian Journal of Endocrinology & Metabolism, 2017, Vol 21, p51
- ISSN
2230-8210
- Publication type
Article