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- Title
Elucidating the molecular healing of intrabony defects following non‐surgical periodontal therapy: A pilot study.
- Authors
Koidou, Vasiliki P.; Hagi‐Pavli, Eleni; Nibali, Luigi; Donos, Nikolaos
- Abstract
Objective: To elucidate the molecular healing of intrabony defects following non‐surgical periodontal therapy (NSPT) using gingival crevicular fluid (GCF). Background Data: Currently limited information is available regarding the GCF of intrabony defects and the change in biomarker levels in the GCF at early time points following treatment interventions. Methods: Twenty‐one patients (Periodontitis Stage III or IV) who have received NSPT, contributing one intrabony defect and one healthy site were included in this study. GCF sampling was performed at baseline, 1 day, 5 days and 3 months after NSPT. Multiplex bead immunoassays allowed the profiling of GCF for 27 markers, associated with inflammation and repair/regeneration. A mixed effects model with Bonferroni correction for multiple comparisons was employed to compare the changes in the levels of GCF markers over time. Results: Following NSPT, changes were observed for several GCF markers, marked by significant increases 1 day post‐intervention, before returning to baseline levels by 3 months. Specifically, GCF concentrations of IL‐2, IL‐4, IL‐6, IL‐8, MMP‐1, MMP‐3, TIMP‐1 and FGFb significantly increased 1 day after NSPT. Signs of activation of cellular senescence were observed 1 day following treatment of intrabony defects, rapidly regressing by 5 days. Conclusion: Significant molecular changes are observed as early as 1 day following NSPT in intrabony defects, along with activation of cellular senescence.
- Subjects
PERIODONTITIS treatment; WOUND healing; BIOMARKERS; PILOT projects; INTERLEUKINS; PROTEINS; BONE resorption; PERIODONTITIS; GROWTH factors; PROTEOLYTIC enzymes; CELL physiology; IMMUNOASSAY; COMPARATIVE studies; EXUDATES &; transudates; DESCRIPTIVE statistics; RESEARCH funding
- Publication
Journal of Periodontal Research, 2024, Vol 59, Issue 1, p53
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/jre.13207