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- Title
Chemical composition and biological activities of the essential oil of Laggera aurita Linn (DC.) grown in Pakistan.
- Authors
Shahwar, Durre; Ahmad, Naeem; Khan, Muhammad Akmal; Ahmad, Saif Ullah Nadeem
- Abstract
Aim: Laggera aurita Linn (DC.) (Asteraceae), an aromatic weed, has significant ethno medicinal use in China. This study was designed to determine xanthine oxidase, antioxidant, and antibacterial activities of the steam distilled volatile oil of Laggera aurita grown in Pakistan. Materials and methods: The volatile oil of the aerial parts of L. aurita was obtained by hydrodistillation and analyzed by GC-MS. The biological activities investigated include xanthine oxidase inhibition and antioxidant activities using UV spectrophotometry and antibacterial activity through agar well diffusion method. Results: GC-MS analysis of the steam distilled volatile oil of L. aurita showed highest concentration of fatty acids (47.5%), followed by sesquiterpenes (30.8%) and hydrocarbons (8.6%). Monoterpenes and phenolic derivatives were observed as the minor components. The volatile oil exhibited significant xanthine oxidase inhibition potential with IC50=0.45 ± 0.009 mg/ml. A dose-dependent increase in the antioxidant potential was observed in DPPH• radical scavenging and total antioxidant assays Among the four selected strains, the essential oil was found more active against Proteus mirabilis (MIC=0.5 mg/ml) and Bacillus subtilis (MIC=1.0 mg/ml). Conclusion: Results of the present study show that the volatile oil of Laggera aurita has significant xanthine oxidase inhibitory potential. In addition, the oil showed high results in the antibacterial assay, comparable with the standard. Further investigation is necessary for the identification of active component.
- Subjects
THERAPEUTIC use of essential oils; ASTERACEAE; DISTILLATION; GAS chromatography/Mass spectrometry (GC-MS); XANTHINE oxidase; ANTIOXIDANTS; ANTIBACTERIAL agents; BACILLUS subtilis
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue 3, p329
- ISSN
0250-4685
- Publication type
Article
- DOI
10.5505/tjb.2012.04706