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- Title
Independent association of HLA-DPB1*02:01 with rheumatoid arthritis in Japanese populations.
- Authors
Furukawa, Hiroshi; Oka, Shomi; Shimada, Kota; Hashimoto, Atsushi; Komiya, Akiko; Tsunoda, Shinichiro; Suda, Akiko; Ito, Satoshi; Saisho, Koichiro; Katayama, Masao; Shinohara, Satoshi; Sato, Takeo; Nagatani, Katsuya; Minota, Seiji; Matsui, Toshihiro; Fukui, Naoshi; Sugii, Shoji; Sano, Hajime; Migita, Kiyoshi; Nagaoka, Shouhei
- Abstract
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized with joint destructions; environmental and genetic factors were thought to be involved in the etiology of RA. The production of anti-citrullinated peptide antibodies (ACPA) is specifically associated with RA. DRB1 is associated with the susceptibility of RA, especially ACPA-positive RA [ACPA(+)RA]. However, a few studies reported on the independent associations of DPB1 alleles with RA susceptibility. Thus, we investigated the independent association of DPB1 alleles with RA in Japanese populations. Methods: Association analyses of DPB1 were conducted by logistic regression analysis in 1667 RA patients and 413 controls. Results: In unconditioned analysis, DPB1*04:02 was nominally associated with the susceptibility of ACPA(+)RA (P = 0.0021, corrected P (Pc) = 0.0275, odds ratio [OR] 1.52, 95% confidence interval [CI] 1.16–1.99). A significant association of DPB1*02:01 with the susceptibility of ACPA(+)RA was observed, when conditioned on DRB1 (Padjusted = 0.0003, Pcadjusted = 0.0040, ORadjusted 1.47, 95%CI 1.19–1.81). DPB1*05:01 was tended to be associated with the protection against ACPA(+)RA, when conditioned on DRB1 (Padjusted = 0.0091, Pcadjusted = 0.1184, ORadjusted 0.78, 95%CI 0.65–0.94). When conditioned on DRB1, the association of DPB1*04:02 with ACPA(+)RA was disappeared. No association of DPB1 alleles with ACPA-negative RA was detected. Conclusion: The independent association of DPB1*02:01 with Japanese ACPA(+)RA was identified.
- Subjects
RHEUMATOID arthritis; JAPANESE people; AUTOIMMUNE diseases; BLOOD hyperviscosity syndrome; RHEUMATISM
- Publication
PLoS ONE, 2018, Vol 13, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0204459