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- Title
Role of mucosal high-risk human papillomavirus types in head and neck cancers in Romania.
- Authors
Ursu, Ramona Gabriela; Danciu, Mihai; Spiridon, Irene Alexandra; Ridder, Ruediger; Rehm, Susanne; Maffini, Fausto; McKay-Chopin, Sandrine; Carreira, Christine; Lucas, Eric; Costan, Victor-Vlad; Popescu, Eugenia; Cobzeanu, Bogdan; Ghetu, Nicolae; Iancu, Luminita Smaranda; Tommasino, Massimo; Pawlita, Michael; Holzinger, Dana; Gheit, Tarik
- Abstract
Background: Limited information is available about the involvement of human papillomavirus (HPV) in head and neck squamous cell carcinomas (HNSCCs) in Romanian patients. Objective: To evaluate the HPV-attributable fraction in HNSCCs collected in Northeastern Romania. Materials and methods: In total, 189 formalin-fixed paraffin-embedded tissue samples (99 oral cavity tumors, 28 oropharynx, 48 pharynx, and 14 larynx/hypopharynx) were analyzed for HPV DNA and RNA using Luminex-based assays, and for overexpression of p16INK4a (p16) by immunohistochemistry. Results: Of the 189 cases, 23 (12.2%) were HPV DNA-positive, comprising half of the oropharyngeal cases (14/28, 50.0%) and 9/161 (5.6%) of the non-oropharyngeal cases. HPV16 was the most prevalent HPV type (20/23, 86.9%), followed by HPV18 (5/23, 21.7%) and HPV39 (1/23, 4.3%). Only two (2/189, 1.1%) HNSCC cases were HPV-driven, i.e. positive for both HPV DNA and RNA. Conclusion: A very small subset of HNSCC cases within this cohort from Northeastern Romania appeared to be HPV-driven.
- Subjects
HEAD &; neck cancer; SQUAMOUS cell carcinoma; CANCER treatment; HUMAN papillomavirus vaccines; PAPILLOMAVIRUSES
- Publication
PLoS ONE, 2018, Vol 13, Issue 6, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0199663