We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Schistosoma Tegument Proteins in Vaccine and Diagnosis Development: An Update.
- Authors
Fonseca, Cristina Toscano; Figueiredo Carvalho, Gardênia Braz; Carvalho Alves, Clarice; Teixeira de Melo, Tatiane
- Abstract
The development of a vaccine against schistosomiasis and also the availability of a more sensitive diagnosis test are important tools to help chemotherapy in controlling disease transmission. Bioinformatics tools, together with the access to parasite genome, published recently, should help generate new knowledge on parasite biology and search for new vaccines or therapeutic targets and antigens to be used in the disease diagnosis. Parasite surface proteins, especially those expressed in schistosomula tegument, represent interesting targets to be used in vaccine formulations and in the diagnosis of early infections, since the tegument represents the interface between host and parasite and its molecules are responsible for essential functions to parasite survival. In this paper we will present the advances in the development of vaccines and diagnosis tests achieved with the use of the information from schistosome genome focused on parasite tegument as a source for antigens.
- Subjects
SCHISTOSOMIASIS diagnosis; SCHISTOSOMIASIS vaccines; DRUG development; DRUG therapy; SCHISTOSOMIASIS; MEDICAL publishing; EXCIPIENTS; GENE expression; ANTIGENS; INFECTIOUS disease transmission
- Publication
Journal of Parasitology Research, 2012, p1
- ISSN
2090-0023
- Publication type
Article
- DOI
10.1155/2012/541268