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- Title
Role of serum IL-6 and TNF-α in coronavirus disease 2019 (COVID-19) associated renal impairment.
- Authors
Chen, Li-Da; Hu, Lan; Song, Yang; Huang, Ya-Ping; Yang, Si-Jiu; Yang, Juan; Zhang, Xiao-bin
- Abstract
Objectives: Association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and kidney injury has been noted in previous studies. However, the mechanisms remain unknown. The present study aimed to explore the potential mechanisms of kidney injury in COVID-19. Methods: Demographic characteristics, underlying diseases, signs, symptoms, and laboratory data of 100 COVID-19 patients were collected and analyzed in this retrospective study. Patients were divided into three groups: mild, moderate, and severe to critical group. Kidney injury was evaluated by markers including estimated glomerular filtration rate (eGFR), serum creatinine, blood urea nitrogen, and cystatin C. Results: A total of 100 patients with 12 mild, 63 moderate, and 25 severe to critical COVID-19 were included in this study. The kidney injury markers including eGFR, serum creatinine, blood urea nitrogen, and cystatin C all worsened significantly with an increase in disease severity. The correlation test showed that cytokines IL-2R, IL-6, IL-8, and tumor necrosis factor (TNF)-α were statistically correlated with eGFR and cystatin C. In multivariate analysis, log IL-6 (β = −0.331, p =.001 for eGFR and β = 0.405, p <.001 for cystatin C) and log TNF-α (β = −0.316, p =.001 for eGFR and β = 0.534, p <.001 for cystatin C) were found to be the major independent predictors of kidney injury. Conclusion: Serum IL-6 and TNF-α levels were the major independent predictors of kidney injury in COVID-19.
- Subjects
SARS-CoV-2; COVID-19; CORONAVIRUS diseases; TUMOR necrosis factors
- Publication
European Journal of Inflammation, 2022, p1
- ISSN
1721-727X
- Publication type
Article
- DOI
10.1177/1721727X221126117