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- Title
Newborn Screening Levels of 17-Hydroxyprogesterone in Very Low Birth Weight Infants and the Relationship to Chronic Lung Disease.
- Authors
Paul, David A.; Mackley, Amy; Bartoshesky, Louis
- Abstract
Objectives: 17-Hydroxyprogesterone (17-OHP), an intermediary hormone in Cortisol synthesis, has been shown to be elevated in premature infants. However, the relationship between levels of 17-OHP with chronic lung disease (CLD) have not been extensively explored. The objective of this study was to determine whether there is an association between CLD and levels of 17-OHP in a population of very low birth weight infants. Study design: Cohort study of very low birth weight infants cared for at a single level 3 NICU during a 3-year period from July 2001-July 2004, n = 435. Infants had a minimum of one screen for 17-OHP. 17-OHP was measured on the 5th day of life and at 2-4 weeks of life as part of the State of Delaware Newborn Screening Program. Statistical analysis included chisquared, Pearson correlation, and logistic regression. Results: Levels of 17-OHP were higher at the time of the 1st screen compared to the 2nd screen (42.2 ± 36.7 vs 23.5 ± 32.3 ng/ml, respectively, p = 0.01). After controlling for potential confounding variables, gestational age and prenatal steroids were independently associated with 17- OHP. However, logistic regression analysis showed no association between a 1 log increase in levels of 17-OHP with the outcomes of CLD (odds ratio 1.7, 95% CI 0.7-3.8), or death and/or CLD (odds ratio 2.1, 95% CI 0.9-4.8). Conclusions: In our population of very low birth weight infants elevated levels of 17-OHP were not associated with the development of CLD.
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2006, Vol 19, Issue 9, p1119
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/jpem.2006.19.9.1119