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- Title
Extreme lactic acidosis type B associated with metformin treatment.
- Authors
Pikwer, Andreas; Vernersson, Einar; Frid, Anders; Sterner, Gunnar
- Abstract
The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations can cause lactic acidosis. We report a case of severe lactic acidosis (pH 6.60) occuring with ostensibly normal therapeutic doses of metformin in the setting of acute renal failure. Continuous veno-venous haemodiafiltration decreased plasma metformin concentrations from 266 lmol/L at presentation to 68 lmol/L, 21 h later. The patient improved rapidly.
- Subjects
LACTIC acidosis; TYPE B behavior; METFORMIN; TREATMENT of acute kidney failure; BLOOD plasma; PHYSIOLOGICAL effects of hydrogen-ion concentration; DRUG dosage; THERAPEUTICS
- Publication
NDT Plus, 2011, Vol 4, Issue 6, p399
- ISSN
1753-0784
- Publication type
Article