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- Title
High-volume versus standard-volume haemofiltration for septic shock patients with acute kidney injury (IVOIRE study): a multicentre randomized controlled trial.
- Authors
Joannes-Boyau, Olivier; Honoré, Patrick; Perez, Paul; Bagshaw, Sean; Grand, Hubert; Canivet, Jean-Luc; Dewitte, Antoine; Flamens, Claire; Pujol, Wilfried; Grandoulier, Anne-Sophie; Fleureau, Catherine; Jacobs, Rita; Broux, Christophe; Floch, Hervé; Branchard, Olivier; Franck, Stephane; Rozé, Hadrien; Collin, Vincent; Boer, Willem; Calderon, Joachim
- Abstract
Purpose: Septic shock is a leading cause of death among critically ill patients, in particular when complicated by acute kidney injury (AKI). Small experimental and human clinical studies have suggested that high-volume haemofiltration (HVHF) may improve haemodynamic profile and mortality. We sought to determine the impact of HVHF on 28-day mortality in critically ill patients with septic shock and AKI. Methods: This was a prospective, randomized, open, multicentre clinical trial conducted at 18 intensive care units in France, Belgium and the Netherlands. A total of 140 critically ill patients with septic shock and AKI for less than 24 h were enrolled from October 2005 through March 2010. Patients were randomized to either HVHF at 70 mL/kg/h or standard-volume haemofiltration (SVHF) at 35 mL/kg/h, for a 96-h period. Results: Primary endpoint was 28-day mortality. The trial was stopped prematurely after enrolment of 140 patients because of slow patient accrual and resources no longer being available. A total of 137 patients were analysed (two withdrew consent, one was excluded); 66 patients in the HVHF group and 71 in the SVHF group. Mortality at 28 days was lower than expected but not different between groups (HVHF 37.9 % vs. SVHF 40.8 %, log-rank test p = 0.94). There were no statistically significant differences in any of the secondary endpoints between treatment groups. Conclusions: In the IVOIRE trial, there was no evidence that HVHF at 70 mL/kg/h, when compared with contemporary SVHF at 35 mL/kg/h, leads to a reduction of 28-day mortality or contributes to early improvements in haemodynamic profile or organ function. HVHF, as applied in this trial, cannot be recommended for treatment of septic shock complicated by AKI.
- Subjects
BLOOD filtration; SEPTIC shock; ACUTE kidney failure; RANDOMIZED controlled trials; INTENSIVE care units; PATIENTS
- Publication
Intensive Care Medicine, 2013, Vol 39, Issue 9, p1535
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-013-2967-z