We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A multiparameter panel method for outcome prediction following aneurysmal subarachnoid hemorrhage.
- Authors
Turck, Natacha; Vutskits, Laszlo; Sanchez-Pena, Paola; Robin, Xavier; Hainard, Alexandre; Gex-Fabry, Marianne; Fouda, Catherine; Bassem, Hadiji; Mueller, Markus; Lisacek, Frédérique; Puybasset, Louis; Sanchez, Jean-Charles
- Abstract
Purpose: Accurate early anticipation of long-term irreversible brain damage during the acute phase of patients with aneurysmal subarachnoid hemorrhage (aSAH) remains difficult. Using a combination of clinical scores together with brain injury-related biomarkers (H-FABP, NDKA, UFD1 and S100β), this study aimed at developing a multiparameter prognostic panel to facilitate early outcome prediction following aSAH. Methods: Blood samples of 141 aSAH patients from two separated cohorts (sets of 28 and 113 patients) were prospectively enrolled and analyzed with 14 months of delay. Patients were admitted within 48 h following aSAH onset. A venous blood sample was withdrawn within 12 h after admission. H-FABP, NDKA, UFD1, S100β and troponin I levels were determined using classical immunoassays. The World Federation of Neurological Surgeons (WFNS) at admission and the Glasgow Outcome Score (GOS) at 6 months were evaluated. Results: In the two cohorts, blood concentration of H-FABP, S100β and troponin I at admission significantly predicted unfavorable outcome (GOS 1-2-3). A multivariate analysis identified a six-parameter panel, including WFNS, H-FABP, S100β, troponin I, NDKA and UFD-1; when at least three of these parameters were simultaneously above cutoff values, prediction of unfavorable outcome reached around 70% sensitivity in both cohorts for 100% specificity. Conclusion: The use of this panel, including four brain injury-related proteins, one cardiac marker and a clinical score, could be a valuable tool to identify aSAH patients at risk of poor outcome.
- Subjects
SUBARACHNOID hemorrhage; CEREBRAL hemorrhage; BRAIN damage; IMMUNOASSAY; TROPONIN I; BRAIN injuries
- Publication
Intensive Care Medicine, 2010, Vol 36, Issue 1, p107
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-009-1641-y