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- Title
Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data.
- Authors
Paules, Catharine I; Gallagher, Shannon K; Rapaka, Rekha R; Davey, Richard T; Doernberg, Sarah B; Grossberg, Robert; Hynes, Noreen A; Ponce, Philip O; Short, William R; Voell, Jocelyn; Wang, Jing; Yang, Otto O; Wolfe, Cameron R; Lye, David C; Dodd, Lori E; Benson, Constance A
- Abstract
This post hoc analysis of the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) shows a treatment effect of remdesivir (RDV) on progression to invasive mechanical ventilation (IMV) or death. Additionally, we create a risk profile that better predicts progression than baseline oxygen requirement alone. The highest risk group derives the greatest treatment effect from RDV.
- Subjects
THERAPEUTIC use of monoclonal antibodies; STATISTICS; DISEASE progression; DRUG efficacy; COVID-19; OPERATIVE surgery; RETROSPECTIVE studies; ARTIFICIAL respiration; TREATMENT effectiveness; RISK assessment; OXYGEN therapy; DEATH; DATA analysis; LONGITUDINAL method
- Publication
Clinical Infectious Diseases, 2022, Vol 74, Issue 7, p1260
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab695