We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hydrostatic pressure sensation in cells: integration into the tensegrity model.
- Authors
Myers, Kenneth A.; Rattner, Jerome B.; Shrive, Nigel G.; Hart, David A.
- Abstract
Hydrostatic pressure (HP) is a mechanical stimulus that has received relatively little attention in the field of the cell biology of mechanotransduction. Generalized models, such as the tensegrity model, do not provide a detailed explanation of how HP might be detected. This is significant, because HP is an important mechanical stimulus, directing cell behaviour in a variety of tissues, including cartilage, bone, airways, and the vasculature. HP sensitivity may also be an important factor in certain clinical situations, as well as under unique environmental conditions such as microgravity. While downstream cellular effects have been well characterized, the initial HP sensation mechanism remains unclear. In vitro evidence shows that HP affects cytoskeletal polymerization, an effect that may be crucial in triggering the cellular response. The balance between free monomers and cytoskeletal polymers is shifted by alterations in HP, which could initiate a cellular response by releasing and (or) activating cytoskeleton-associated proteins. This new model fits well with the basic tenets of the existing tensegrity model, including mechanisms in which cellular HP sensitivity could be tuned to accommodate variable levels of stress.
- Subjects
HYDROSTATIC pressure; CYTOLOGY; MATHEMATICAL models; CELLS; SENSES; REDUCED gravity environments
- Publication
Biochemistry & Cell Biology, 2007, Vol 85, Issue 5, p543
- ISSN
0829-8211
- Publication type
Article
- DOI
10.1139/O07-108