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- Title
A consensus epitope prediction approach identifies the breadth of murine T<sub>CD8+</sub>-cell responses to vaccinia virus.
- Authors
Moutaftsi, Magdalini; Peters, Bjoern; Pasquetto, Valerie; Tscharke, David C.; Sidney, John; Huynh-Hoa Bui; Grey, Howard; Sette, Alessandro
- Abstract
The value of predictive algorithms for identifying CD8+ T (TCD8+)-cell epitopes has not been adequately tested experimentally. Here we demonstrate that conventional bioinformatic methods predict the vast majority of TCD8+-cell epitopes derived from vaccinia virus WR strain (VACV-WR) in the H-2b mouse model. This approach reveals the breadth of T-cell responses to vaccinia, a widely studied murine viral infection model, and may provide a tool for developing comprehensive antigenic maps of any complex pathogen.
- Subjects
EPITOPES; VACCINIA; VIRUS diseases in cattle; PATHOGENIC microorganisms; IMMUNOSPECIFICITY; VIRUS diseases
- Publication
Nature Biotechnology, 2006, Vol 24, Issue 7, p817
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt1215