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- Title
Engineering tolerance and accumulation of lead and cadmium in transgenic plants.
- Authors
Song, Won-Yong; Ju Sohn, Eun; Martinoia, Enrico; Jik Lee, Yong; Yang, Young-Yell; Jasinski, Michal; Forestier, Cyrille; Hwang, Inwhan; Lee, Youngsook
- Abstract
We have studied the utility of the yeast protein YCF1, which detoxifies cadmium by transporting it into vacuoles, for the remediation of lead and cadmium contamination. We found that the yeastYCF1-deletion mutant DTY167 was hypersensitive to Pb(II) as compared with wild-type yeast. DTY167 cells overexpressingYCF1 were more resistant to Pb(II) and Cd(II) than were wild-type cells, and accumulated more lead and cadmium. Analysis of transgenicArabidopsis thaliana plants overexpressing YCF1 showed that YCF1 is functionally active and that the plants have enhanced tolerance of Pb(II) and Cd(II) and accumulated greater amounts of these metals. These results suggest that transgenic plants expressingYCF1 may be useful for phytoremediation of lead and cadmium.
- Subjects
YEAST; DETOXIFICATION (Substance abuse treatment); PHYTOREMEDIATION; CADMIUM; LEAD; THERAPEUTICS
- Publication
Nature Biotechnology, 2003, Vol 21, Issue 8, p914
- ISSN
1087-0156
- Publication type
Article
- DOI
10.1038/nbt850