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- Title
Presentation and outcomes of patients with clinically T1‐2, N0 supraglottic squamous cell carcinoma: The role of definitive radiotherapy compared to primary partial laryngectomy.
- Authors
Al‐Qurayshi, Zaid; Ngouajio, Amanda L.; Buchakjian, Marisa R.
- Abstract
Background: Early‐stage supraglottic squamous cell carcinoma (SCC) is usually treated with a single modality. The aim of this study is to examine the role of radiotherapy (RT) versus partial laryngectomy (open, robotic‐assisted, or endoscopic) with elective neck dissection (PL + END). Methods: A retrospective analysis of the National Cancer Database, 2010–2016. The study population included adult patients with clinically T1‐2, N0 supraglottic SCC. Results: 3301 patients were included. RT was performed in 93.52%, open PL + END in 2.64%, robotic‐assisted PL + END in 1.33%, and endoscopic surgical resection in 2.51%. In the surgery group, T was upstaged in 23.36% and N was upstage in 16.36%. Five‐year survival in the primary surgery group compared to RT group was 61.89% versus 77.46% (HR: 0.56, 95%CI: 0.43, 0.72). Conclusions: T was upstaged in 23% of surgical patients. This accurate staging is likely missed in patients who undergo RT and possibly contributes to lower overall survival of this treatment group.
- Subjects
LARYNGECTOMY; SQUAMOUS cell carcinoma; ACCELERATED partial breast irradiation; ENDOSCOPIC surgery; TREATMENT effectiveness; SURGICAL excision; RADIOTHERAPY
- Publication
Head & Neck, 2022, Vol 44, Issue 3, p735
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26966