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- Title
Matrix control of scarring.
- Authors
Yates, Cecelia; Bodnar, Richard; Wells, Alan
- Abstract
Repair of wounds usually results in restoration of organ function, even if suboptimal. However, in a minority of situations, the healing process leads to significant scarring that hampers homeostasis and leaves the tissue compromised. This scar is characterized by an excess of matrix deposition that remains poorly organized and weakened. While we know much of the early stages of the repair process, the transition to wound resolution that limits scar formation is poorly understood. This is particularly true of the inducers of scar formation. Here, we present a hypothesis that it is the matrix itself that is a primary driver of scar, rather than being simply the result of other cellular dysregulations.
- Subjects
SCARS; EXTRACELLULAR matrix proteins; WOUND healing; FIBROSIS; FIBRONECTINS; TENASCIN; HOMEOSTASIS
- Publication
Cellular & Molecular Life Sciences, 2011, Vol 68, Issue 11, p1871
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-011-0663-0