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- Title
Time course of changes in jugular venous oxygen saturation during hypothermic or normothermic cardiopulmonary bypass in patients with diabetes mellitus.
- Authors
Kadoi, Y.; Saito, S.; Goto, F.; Someya, T.; Kamiyashiki, S.; Fujita, N.
- Abstract
<bold>Background: </bold>Preexisting diabetic mellitus is a risk factor determining postoperative neurological disorders. The present study assesses the effects of normothermic and hypothermic cardiopulmonary bypass (CPB) on jugular venous oxygen saturation (SjvO2)in patients with preexisting diabetic mellitus.<bold>Methods: </bold>Sixteen diabetic patients who underwent elective coronary artery bypass grafting surgery were randomly divided into two groups: Group DN (n=8, diabetic patients) underwent normothermic CPB (>35 degrees C), and group DH (n=8, diabetic patients) underwent hypothermic CPB (32 degrees C). Controls were 16 age-matched non-diabetic patients (normothemic group, CN: n=8; hypothemic group, CH: n=8). A 4.0 F fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to continuously monitor SjvO2 values. Hemodynamic parameters and arterial and jugular venous blood gases were measured seven times.<bold>Results: </bold>Cerebral desaturation, which was defined as SjvO2 values below 50%, was observed during normothermic CPB in diabetic patients (at the onset of CPB: 46+/-3%, at 20 min after onset of CPB: 49+/-3%, means+/-SD, respectively). No cerebral desaturation occurred in diabetic and control patients during hypothermic CPB.<bold>Conclusions: </bold>Patients with preexisting diabetes mellitus experienced cerebral desaturation during normothermic CPB.
- Subjects
CARDIOPULMONARY bypass; DIABETES; PATIENTS; DIABETES complications; BLOOD gases analysis; CLINICAL trials; COMPARATIVE studies; HEMATOCRIT; HEMODYNAMICS; INDUCED hypothermia; INTRAOPERATIVE monitoring; JUGULAR vein; RESEARCH methodology; MEDICAL cooperation; OXYGEN; RESEARCH; RISK assessment; EVALUATION research; RANDOMIZED controlled trials; CARDIOPLEGIC solutions
- Publication
Acta Anaesthesiologica Scandinavica, 2001, Vol 45, Issue 7, p858
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1034/j.1399-6576.2001.045007858.x