We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Effect of Continuous Veno-Venous Haemofiltration (CVVH) on Inflammatory Mediators in Sepsis.
- Authors
Cader, Rizna Abdul; Hassan, Juita; Kong, Norella C. T.; Gafor, Halim Abdul; Mohd, Rozita; Mohammad, Marlyn; Hod, Rozita
- Abstract
Objective: Continuous Veno-Venous Haemofiltration (CVVH) is an extracorporeal treatment that removes inflammatory mediators thereby improving haemodynamic stability in sepsis. We wanted to determine the efficacy of CVVH in addition to standard therapy for sepsis in terms of plasma inflammatory mediators and the association of inflammatory mediators with 30 day outcome. Design: Prospective study involving septic patients with or without acute kidney injury at our institution. Materials and Methods: All patients received CVVH in addition to fluid resuscitation and antibiotics. Haemodynamic parameters including ionotropic requirements and inflammatory mediators including CRP, procalcitonin (PCT), IL-6 and IL-10 were measured before and after 24 hours of treatment. Results: 22 patients (16M: 5F, mean age 59.0 ± 15.7 years) completed the study. There was an improvement in haemodynamic stability with an increase in diastolic blood pressure (p = 0.036) without any increment in inotropic support. There was a reduction in serum PCT and CRP (p = 0.007 and p = 0.031) after completion of CVVH. Similarly, serum IL-6 reduced (p = 0.003) but there was no increment in IL-10 at the end of CVVH. There were positive correlations between CRP and PCT (p = 0.035) and IL-6 and IL-10 (p < 0.001). There was an inverse correlation between serum IL-6 and albumin (p = 0.001) and IL-10 and albumin (p = 0.004). Conclusion: CVVH has a positive effect on inflammatory biomarkers thereby enhancing haemodynamic stability in septic patients.
- Subjects
BLOOD filtration; INFLAMMATORY mediators; INTERLEUKINS; LONGITUDINAL method; MULTIPLE organ failure; SEPSIS
- Publication
International Medical Journal, 2016, Vol 23, Issue 4, p319
- ISSN
1341-2051
- Publication type
Article