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- Title
Factor Analysis of Lifestyle-Related Diseases Including GFR and Uric Acid in Japanese Adults.
- Authors
Hasegawa, Takashi; Fujikawa, Mariko
- Abstract
Objective: This study investigated clustering patterns of the estimated glomerular filtration rate (eGFR) and several lifestyle-related factors in urban Japanese subjects. Design: Cross-sectional study Methods: Data of ten factors including age, frequency of physical exercise, body mass index (BMI), mean blood pressure (MBP), fasting plasma glucose (FPG), serum total cholesterol (TC), serum triglyceride/high- density lipoprotein cholesterol ratio (TG/HDLc), gamma-glutamyltransferase (γ GTP), serum uric acid (DA), and eGFR, were analyzed in 33,565 (8,080 men; 25,485 women) individuals aged 20-69 years in an urban Japanese population. The data were subjected to factor analysis, which reduced the variables to three factors in both genders. Results: The first factor was obesity and related factors, the second factor was uric acid and related factors, and the third factor was aging and related factors. Changes in eGFR were influenced mainly by aging in young adults, while in individuals older than 40 years, these changes were determined primarily by UA levels. Conclusion: These findings indicated that uric acid may have a major influence factor on the levels of eGFR. No correlation was noted between eGFR and metabolic factors represented by obesity, hypertension, and dyslipidemia.
- Subjects
JAPAN; OBESITY; AGING; ANALYSIS of variance; BLOOD pressure; BLOOD sugar; CHOLESTEROL; CHRONIC diseases; CLUSTER analysis (Statistics); COMPUTER software; ENZYMES; EXERCISE; FACTOR analysis; GLOMERULAR filtration rate; HIGH density lipoproteins; KIDNEY diseases; STATISTICS; TRIGLYCERIDES; U-statistics; URIC acid; DATA analysis; BODY mass index; DISEASE prevalence; CROSS-sectional method; ADULTS; BLOOD; ANALYTICAL chemistry; EPIDEMIOLOGY
- Publication
International Medical Journal, 2010, Vol 17, Issue 3, p167
- ISSN
1341-2051
- Publication type
Article