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- Title
Hippocampal Function in Healthy Carriers of the CLU Alzheimer's Disease Risk Variant.
- Authors
Erk, Susanne; Meyer-Lindenberg, Andreas; von Boberfeld, Carola Opitz; Esslinger, Christine; Schnell, Knut; Kirsch, Peter; Mattheisen, Manuel; Mühleisen, Thomas W.; Cichon, Sven; Witt, Stephanie H.; Rietschel, Marcella; Nöthen, Markus M.; Walter, Henrik
- Abstract
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
- Subjects
HIPPOCAMPUS (Brain); BRAIN function localization; ALZHEIMER'S disease; DISEASE progression; PREFRONTAL cortex; CLINICAL trials; MEMORY
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 49, p18180
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4960-11.2011