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- Title
Large-Scale Automated Histology in the Pursuit of Connectomes.
- Authors
Kleinfeld, David; Bharioke, Arjun; Blinder, Pablo; Bock, Davi D.; Briggman, Kevin L.; Chklovskii, Dmitri B.; Denk, Winfried; Helmstaedter, Moritz; Kaufhold, John P.; Wei-Chung Allen Lee; Meyer, Hanno S.; Micheva, Kristina D.; Oberlaender, Marcel; Prohaska, Steffen; Reid, R. Clay; Smith, Stephen J.; Takemura, Shinya; Tsai, Philbert S.; Sakmann, Bert
- Abstract
How does the brain compute? Answering this question necessitates neuronal connectomes, annotated graphs of aU synaptic connections within defined brain areas. Further, understanding the energetics of the brain's computations require vascular graphs. The a embly of a connectomc requires sensitive hardware tools to measure neuronal and neurovascular features in all three dimensions, as weU as software and machine learning for data analysis and visualization. We present the state of the art on the reconstruction of circuits and vasculature that link brain anatomy and function. Analysis at the scale of tens of nanometers yields connections between identified neurons, while analysis at the micrometer scale yields probabilistic rules of connection between neurons and exact vascular connectivity.
- Subjects
HISTOLOGY; NEUROPLASTICITY; NEURAL circuitry; BRAIN function localization; DATA analysis; VISUALIZATION; NEURONS
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 45, p16125
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.4077-11.2011