We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Striatal Dopamine D<sub>2</sub>/D<sub>3</sub> Receptor Availability Is Reduced in Methamphetamine Dependence and Is Linked to Impulsivity.
- Authors
Lee, Buyean; London, Edythe D.; Poldrack, Russell A.; Farahi, Judah; Nacca, Angelo; Monterosso, John R.; Mumford, Jeanette A.; Bokarius, Andrew V.; Dahlbom, Magnus; Mukherjee, Jogeshwar; Bilder, Robert M.; Brody, Arthur L.; Mandelkern, Mark A.
- Abstract
While methamphetamine addiction has been associated with both impulsivity and striatal dopamine D2/D3 receptor deficits, human studies have not directly linked the latter two entities. We therefore compared methamphetamine-dependent and healthy control subjects using the Barratt Impulsiveness Scale (version 11, BIS-11) and positron emission tomography with [18F]fallypride to measure striatal dopamine D2/D3 receptor availability. The methamphetamine-dependent subjects reported recent use of the drug 3.3 g per week, and a history of using methamphetamine, on average, for 12.5 years. They had higher scores than healthy control subjects on all BIS-11 impulsiveness subscales ( p < 0.001). Volume-of-interest analysis found lower striatal D2/D3 receptor availability in methamphetamine-dependent than in healthy control subjects ( p < 0.01) and a negative relationship between impulsiveness and striatal D2/D3 receptor availability in the caudate nucleus and nucleus accumbens that reached statistical significance in methamphetamine-dependent subjects. Combining data from both groups, voxelwise analysis indicated that impulsiveness was related to D2/D3 receptor availability in left caudate nucleus and right lateral putamen/claustrum ( p < 0.05, determined by threshold-free cluster enhancement). In separate group analyses, correlations involving the head and body of the caudate and the putamen of methamphetamine-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker threshold ( p < 0.12 corrected). The findings suggest that low striatal D2/D3 receptor availability may mediate impulsive temperament and thereby influence addiction.
- Subjects
METHAMPHETAMINE; DOPAMINE; NEUROTRANSMITTERS; POSITRON emission; NEURAL receptors
- Publication
Journal of Neuroscience, 2009, Vol 29, Issue 47, p14734
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.3765-09.2009