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- Title
Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort Study.
- Authors
Noh, Ji Yun; Yang, Jeong Sun; Hwang, Soon Young; Hyun, Hakjun; Seong, Hye; Yoon, Jin Gu; Yoon, Soo Young; Cheong, Hee Jin; Kim, Woo Joo; Park, Woo Jung; Kim, Jun Won; Lee, Joo Yeon; Song, Joon Young; Gu Yoon, Jin
- Abstract
A prospective cohort study was conducted for adults with a diagnosis of with coronavirus disease 2019 (COVID-19). Convalescent blood samples were obtained 4, 6, and 11 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The seropositivity of anti-spike antibody was maintained in all patients (100%) until 11 months after COVID-19 diagnosis. Neutralizing antibody levels against wild-type SARS-CoV-2 gradually decreased but remained positive in >50% of patients 11 months after diagnosis: in 98.5% (67 of 68) at 4 months, 86.8% (46 of 53) at 6 months, and 58.8% (40 of 68) at 11 months. However, cross-neutralizing activity against the Beta and Delta variants was attenuated 2.53-fold and 2.93-fold, respectively, compared with the wild-type strain.
- Subjects
COVID-19; SARS-CoV-2; SARS-CoV-2 Delta variant; CORONAVIRUS diseases; HUMORAL immunity; ALPHA rhythm
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 6, p975
- ISSN
0022-1899
- Publication type
Case Study
- DOI
10.1093/infdis/jiac050