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- Title
A Gonococcal Vaccine Has the Potential to Rapidly Reduce the Incidence of Neisseria gonorrhoeae Infection Among Urban Men Who Have Sex With Men.
- Authors
Hui, Ben B; Padeniya, Thilini N; Rebuli, Nic; Gray, Richard T; Wood, James G; Donovan, Basil; Duan, Qibin; Guy, Rebecca; Hocking, Jane S; Lahra, Monica M; Lewis, David A; Whiley, David M; Regan, David G; Seib, Kate L
- Abstract
<bold>Background: </bold>A gonococcal vaccine is urgently needed due to increasing gonorrhea incidence and emerging multidrug-resistant gonococcal strains worldwide. Men who have sex with men (MSM) have among the highest incidences of gonorrhea and may be a key target population for vaccination when available.<bold>Methods: </bold>An individual-based, anatomical site-specific mathematical model was used to simulate Neisseria gonorrhoeae transmission in a population of 10 000 MSM. The impact of vaccination on gonorrhea prevalence was assessed.<bold>Results: </bold>With a gonococcal vaccine of 100% or 50% protective efficacy, gonorrhea prevalence could be reduced by 94% or 62%, respectively, within 2 years if 30% of MSM are vaccinated on presentation for sexually transmitted infection (STI) testing. Elimination of gonorrhea is possible within 8 years with vaccines of ≥ 50% efficacy lasting 2 years, providing a booster vaccination is available every 3 years on average. A vaccine's impact may be reduced if it is not effective at all anatomical sites.<bold>Conclusions: </bold>Our study indicates that with a vaccine of modest efficacy and an immunization strategy that targets MSM presenting for STI screening, the prevalence of gonorrhea in this population could be rapidly and substantially reduced.
- Subjects
GONORRHEA; NEISSERIA gonorrhoeae; MEN who have sex with men; SEXUALLY transmitted diseases; BOOSTER vaccines; VACCINE effectiveness; GONORRHEA prevention; RESEARCH; RESEARCH methodology; DISEASE incidence; EVALUATION research; HOMOSEXUALITY; COMPARATIVE studies; NEISSERIA; IMPACT of Event Scale; RESEARCH funding; BACTERIAL vaccines
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 6, p983
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab581