We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection.
- Authors
Arcanjo, Angélica; Pinto, Kamila Guimarães; Logullo, Jorgete; Leite, Paulo Emílio Corrêa; Menezes, Camilla Cristie Barreto; Freire-de-Lima, Leonardo; Diniz-Lima, Israel; Decoté-Ricardo, Debora; Rodrigues-da-Silva, Rodrigo Nunes; Freire-de-Lima, Celio Geraldo; Filardy, Alessandra Almeida; Lima-Junior, Josué da Costa; Bertho, Alvaro Luiz; Luca, Paula Mello De; Granjeiro, José Mauro; Barroso, Shana Priscila Coutinho; Conceição-Silva, Fátima; Savino, Wilson; Morrot, Alexandre; De Luca, Paula Mello
- Abstract
<bold>Background: </bold>Coronavirus disease 2019 (COVID-19) can progress to severe pneumonia with respiratory failure and is aggravated by the deregulation of the immune system causing an excessive inflammation including the cytokine storm.<bold>Methods: </bold>In this study, we report that severe acutely infected patients have high levels of both type-1 and type-2 cytokines.<bold>Results: </bold>Our results show abnormal cytokine levels upon T-cell stimulation, in a nonpolarized profile. Furthermore, our findings indicate that this hyperactive cytokine response is associated with a significantly increased frequency of late-differentiated T cells with particular phenotype of effector exhausted/senescent CD28-CD57+ cells. Of note, we demonstrated for the first time an increased frequency of CD3+CD4+CD28-CD57+ T cells with expression of programmed death 1, one of the hallmarks of T-cell exhaustion.<bold>Conclusions: </bold>These findings reveal that COVID-19 is associated with acute immunodeficiency, especially within the CD4+ T-cell compartment, and points to possible mechanisms of loss of clonal repertoire and susceptibility to viral relapse and reinfection events.
- Subjects
COVID-19; T cells; CYTOKINES; CRITICALLY ill; CYTOKINE release syndrome
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 10, p1672
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab425