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- Title
CXCL17 induces activation of human mast cells via MRGPRX2.
- Authors
Ding, Jie; Hillig, Christina; White, Carl W.; Fernandopulle, Nithya A.; Anderton, Holly; Kern, Johannes S.; Menden, Michael P.; Mackay, Graham A.
- Abstract
This article discusses the activation of mast cells (MCs) through the Mas-related G protein-coupled receptor X2 (MRGPRX2) pathway. The study focuses on the chemokine CXCL17, which is expressed in mucosal tissues and has antimicrobial properties. The researchers found that CXCL17 activates human MCs via the MRGPRX2 pathway, and this activation may be important in inflammatory conditions such as psoriasis. The study also provides evidence of increased expression of CXCL17 in psoriatic skin, particularly in areas proximal to MRGPRX2-positive MCs. Further research is needed to understand the role of CXCL17-induced MC activation in psoriasis and other inflammatory skin diseases.
- Subjects
TRYPTASE; MAST cells; ITCHING; MYELOID-derived suppressor cells; G protein coupled receptors; REGULATORY T cells; ANTIMICROBIAL peptides
- Publication
Allergy, 2024, Vol 79, Issue 6, p1609
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.16036