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- Title
Genetic Influences on the Pharmacokinetics of Orally and Intravenously Administered Digoxin as Exhibited by Monozygotic Twins.
- Authors
Birkenfeld, A. L.; Jordan, J.; Hofmann, U.; Busjahn, A.; Franke, G.; Krüger, N.; Igel, S.; Mürdter, T.; Drescher, S.; Shi, S.; Engeli, S.; Schwab, M.; Eichelbaum, M.; Luft, F. C.; Fromm, M. F.
- Abstract
The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
- Subjects
P-glycoprotein; PHARMACOLOGY; GLYCOPROTEINS; DIGOXIN; CARDENOLIDES
- Publication
Clinical Pharmacology & Therapeutics, 2009, Vol 86, Issue 6, p605
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2009.170