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- Title
Tanis: a link between type 2 diabetes and inflammation?
- Authors
Walder, Ken; Kantham, Lakshmi; McMillan, Janine S; Trevaskis, James; Kerr, Lyndal; Silva, Andrea de; Sunderland, Terry; Godde, Nathan; Gao, Yuan; Bishara, Natalie; Windmill, Kelly; Tenne-Brown, Janette; Augert, Guy; Zimmet, Paul Z; Collier, Greg R; De Silva, Andrea
- Abstract
Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct proportion with plasma triglyceride concentrations (P = 0.007). Hepatic Tanis gene expression was markedly increased (3.1-fold) after a 24-h fast in diabetic but not in nondiabetic P. obesus. In addition, glucose inhibited Tanis gene expression in cultured hepatocytes (P = 0.006) as well as in several other cell types (P = 0.001-0.011). Thus, Tanis seems to be regulated by glucose and is dysregulated in the diabetic state. Yeast-2 hybrid screening identified serum amyloid A (SAA), an acute-phase inflammatory response protein, as an interacting protein of Tanis, and this was confirmed by Biacore experiments. SAA and other acute-phase proteins have been the focus of recent attention as risk factors for cardiovascular disease, and we contend that Tanis and its interaction with SAA may provide a mechanistic link among type 2 diabetes, inflammation, and cardiovascular disease.
- Subjects
PROTEINS; TYPE 2 diabetes; GENE expression
- Publication
Diabetes, 2002, Vol 51, Issue 6, p1859
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.51.6.1859