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- Title
Antidiabetic potential of methanolic leaf extracts of Icacina trichantha in alloxan-induced diabetic mice.
- Authors
Ezeigbo, Ihechiluru I.
- Abstract
Background: The effect of the methanolic leaf extracts of Icacina trichantha on blood glucose levels in alloxan-induced diabetes in mice was investigated. Methods: Hyperglycemia was induced by the injection of 150 mg/kg (i.p.) of alloxan monohydrate freshly dissolved in distilled water. Three doses (200, 300, and 450 mg/kg) per os, of the extracts were administered in the study. The activity was compared with reference standard glibenclamide (2 mg/kg, p.o.) and negative control. Results: Treatment of alloxan-induced diabetic mice with the crude extract of I. trichantha leaves brought down the raised blood glucose levels significantly (P < 0.01) in a dose-dependent manner. Conclusion: The result suggests that I. trichantha possesses antidiabetic property.
- Subjects
ALLOXAN; DIABETES; ICACINACEAE; HYPERGLYCEMIA; OBESE-hyperglycemic syndrome; HYPOGLYCEMIC agents
- Publication
International Journal of Diabetes in Developing Countries, 2010, Vol 30, Issue 3, p150
- ISSN
0973-3930
- Publication type
Article
- DOI
10.4103/0973-3930.66511