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- Title
Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional Study.
- Authors
Omma, Ahmet; Erden, Abdulsamet; Güven, Serdar Can; Ateş, İhsan; Küçükşahin, Orhan
- Abstract
Objective: The aim of this study is to investigate post-COVID-19 antibody titers in patients who received convalescent plasma (CP) in addition to standard-of-care treatment. Materials and Methods: Hospitalized COVID-19 patients who received CP in addition to standard care were retrospectively investigated. Patients who received CP with a recorded total COVID-19 antibody test result after treatment were included. From among hospitalized COVID-19 patients who received only standard care with a recorded total COVID-19 antibody test result, a control group matched for age, gender, and comorbidities was formed. Total COVID-19 antibody index levels were compared. Results: Thirty-three CP recipients were enrolled in the study. The control group consisted of 34 age-, gender-, and comorbidity-matched standard-care patients. Median total COVID-19 antibody index levels were significantly reduced in the CP group. Conclusion: Although CP therapy may have benefits for disease outcome, its potential ability to hamper long-term immunity may be a problem.
- Subjects
COVID-19; ACQUISITION of data methodology; CROSS-sectional method; RETROSPECTIVE studies; TREATMENT effectiveness; ANTIBODY formation; CONVALESCENT plasma; MEDICAL records; IMMUNITY; VIRAL antibodies; EVALUATION
- Publication
Turkish Journal of Hematology, 2021, Vol 38, Issue 4, p321
- ISSN
1300-7777
- Publication type
Article
- DOI
10.4274/tjh.galenos.2021.2021.0277