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- Title
Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice.
- Authors
Yariwake, Victor Yuji; Torres, Janaína Iannicelli; dos Santos, Amandda Rakell Peixoto; Freitas, Sarah Cristina Ferreira; De Angelis, Kátia; Farhat, Sylvia Costa Lima; Câmara, Niels Olsen Saraiva; Veras, Mariana Matera
- Abstract
Background: Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Results: Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. Conclusions: This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.
- Subjects
SYSTEMIC lupus erythematosus; KIDNEY cortex; AIR pollutants; AIR pollution; PARTICULATE matter
- Publication
Particle & Fibre Toxicology, 2021, Vol 18, Issue 1, p1
- ISSN
1743-8977
- Publication type
Article
- DOI
10.1186/s12989-021-00407-0