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- Title
Intrathecal synthesis of anti-Hu antibodies distinguishes patients with paraneoplastic peripheral neuropathy and encephalitis.
- Authors
Schwenkenbecher, Philipp; Priya Chacko, Lisa; Wurster, Ulrich; Pars, Kaweh; Pul, Refik; Sühs, Kurt-Wolfram; Stangel, Martin; Skripuletz, Thomas; Chacko, Lisa Priya
- Abstract
<bold>Background: </bold>Paraneoplastic syndromes are serious immune caused diseases of the peripheral and/or central nervous system associated with malignant neoplasm. Symptoms develop when antibodies against antigens expressed by tumor cells cross-react with neuronal proteins. Antineuronal antibodies are usually examined in patient's sera while examination of the cerebrospinal fluid (CSF) often fails. Furthermore, the few previous reports describing CSF data summarized different antineuronal antibodies and/or regarded patients with different neurological symptoms as one group.<bold>Methods: </bold>We retrospectively evaluated data of 18 patients with paraneoplastic syndromes due to anti-Hu antibodies. The study aimed to differentiate patients with peripheral neuropathy and encephalitis by cerebrospinal fluid (CSF) parameters including anti-Hu antibody titers.<bold>Results: </bold>Our results confirm previous observations that serum titers of anti-Hu antibodies and standard CSF values do not differ between patients with neuropathy and encephalitis. However, analysis of CSF anti-Hu titers and calculating the intrathecal synthesis helped to discriminate between both groups.<bold>Conclusion: </bold>In conclusion, our results indicate that patients even with one defined antineuronal antibody need to be regarded separately depending on the involved location of the nervous system. We recommend incorporation of anti-Hu analyses in the CSF and calculating the intrathecal synthesis in patients with anti-Hu syndrome.
- Subjects
PARANEOPLASTIC syndromes; THERAPEUTIC use of immunoglobulins; TREATMENT of peripheral neuropathy; DIABETIC neuropathies; TREATMENT of encephalitis; THERAPEUTICS; DIAGNOSIS of neurological disorders; AUTOANTIBODIES; NEUROLOGICAL disorders; RETROSPECTIVE studies; DIAGNOSIS
- Publication
BMC Neurology, 2016, Vol 16, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-016-0657-5