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- Title
Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage.
- Authors
Joseph, Troy W.; Zaika, Alex; Moll, Ute M.
- Abstract
Provides information on a study which indicated that in nonlethal outcomes of cellular stress, both nuclear and cytoplasmic proteasomes, are recruited. Description of the principal regulator of p53 stability; Findings from the use of forced over expression of HDM2 in mutant p53 tumor cells; Overview of cell culture and reagents.
- Subjects
CYTOPLASM; CELLS; CELL culture; CULTURES (Biology); CYTOLOGICAL techniques; BIOLOGICAL reagents
- Publication
FASEB Journal, 2003, Vol 17, Issue 12, p1622
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.02-0931com