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- Title
S100A12 and vascular endothelial growth factor can differentiate Blau syndrome and familial Mediterranean fever from systemic juvenile idiopathic arthritis.
- Authors
Yamasaki, Yuichi; Takei, Syuji; Imanaka, Hiroyuki; Kubota, Tomohiro; Nonaka, Yukiko; Takezaki, Tomoko; Kawano, Yoshifumi
- Abstract
Objectives: Systemic juvenile idiopathic arthritis (sJIA) has recently become regarded as one of the autoinflammatory syndromes (AIS). However, other AIS, such as familial Mediterranean fever (FMF) and Blau syndrome, have been initially misdiagnosed as sJIA because of the clinical similarities. Making the correct diagnosis in the early stage of these AIS is desirable. Therefore, we evaluated serum S100A12 and vascular endothelial growth factor (VEGF) levels to determine if they could be biomarkers for differentiating these AIS.Method: Serum S100A12 and VEGF levels were examined in patients with Blau syndrome (n = 4), FMF (n = 4), and sJIA (n = 11) in the active and inactive phases.Results: In the active phase, S100A12 levels were significantly higher in patients with sJIA and FMF compared with those with Blau syndrome (p < 0.001). VEGF levels of patients with sJIA were significantly higher than those of patients with others (p = 0.001). In the inactive phase, there was no significant difference in VEGF levels. However, colchicine-resistant patients or patients without treatment with FMF showed high levels of S100A12 compared with others.Conclusions: Measuring both serum S100A12 and VEGF levels may be useful for differentiating patients with Blau syndrome and FMF from those with sJIA at the early stage.
- Subjects
MACROPHAGE activation syndrome; VASCULAR endothelial growth factors; JUVENILE idiopathic arthritis; FAMILIAL Mediterranean fever
- Publication
Clinical Rheumatology, 2019, Vol 38, Issue 3, p835
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-018-4359-9