We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Androgens Promote Preosteoblast Differentiation via Activation of the Canonical Wnt Signaling Pathway.
- Authors
LIU, XIN‐HUA; KIRSCHENBAUM, ALEXANDER; YAO, SHEN; LEVINE, ALICE C.
- Abstract
Although androgens stimulate bone formation the precise events underlying these effects have not been elucidated. Wnt signaling plays a central role in osteoblast development and bone formation. We demonstrated that dihydrotestosterone (DHT) significantly stimulates MC3T3 preosteoblast differentiation with no effect on cell growth. This effect of DHT was accompanied by increased Wnt signaling in the same cells. Moreover, the stimulatory effects of DHT on preosteoblast differentiation were inhibited by overexpression of soluble frizzed-related protein (sFRP), a naturally occurring Wnt antagonist. These results suggest that androgens promote preosteoblastic differentiation via effects on the canonical Wnt signaling pathway.
- Subjects
ANDROGENS; WNT proteins; GROWTH factors; BONE growth; STANOLONE; PERFORMANCE-enhancing drugs; CELL growth; PROTEINS; SKELETAL maturity
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1116, p423
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1402.017