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- Title
Diagnosis of membranous nephropathy with Anti-GBM glomerulonephritis: a case series report.
- Authors
Liu, Ge; Feng, Xinyan; Yu, Shuangyan; Sheng, Jie; Liu, Chunyan; Wang, Lihua
- Abstract
Background: The concomitant occurrence of membranous nephropathy and anti-glomerular basement (anti-GBM) disease has been previously described but is extremely rare. However, delayed recognition or misdiagnosis leads to delayed treatment, resulting in worse renal and patient outcomes. Case presentation: We present 3 patients with rapidly progressive glomerulonephritis (RPGN), anti-GBM and serum-positive M-type phospholipase A2 receptor (anti-PLA2R) antibody. Renal biopsies revealed PLA2R-associated membranous nephropathy with anti-GBM glomerulonephritis. We analyzed the clinical and pathological characteristics and discussed that the correct diagnosis of membranous nephropathy with anti-GBM should rely on a combination of renal biopsy findings and serological testing. Despite aggressive treatment, one patient received maintenance hemodialysis, one patient progressed to CKD 3 stage, and the other patient died of cerebral infarction. Conclusion: The simultaneous occurrence of membranous nephropathy and anti-GBM disease is extremely rare. The correct diagnosis of membranous nephropathy with anti-GBM relies on a combination of renal biopsy findings and serological testing. Early diagnosis is needed to improve the renal dysfunction.
- Subjects
KIDNEY glomerulus diseases; GLOMERULONEPHRITIS; KIDNEY diseases; ANTI-glomerular basement membrane disease; DIAGNOSIS; PHOSPHOLIPASE A2
- Publication
BMC Nephrology, 2024, Vol 25, Issue 1, p1
- ISSN
1471-2369
- Publication type
Article
- DOI
10.1186/s12882-024-03637-4