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- Title
Transporting and Shielding Photosensitisers by Using Water-Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy.
- Authors
Therrien, Bruno
- Abstract
Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.
- Subjects
PHOTOSENSITIVITY; ORGANOMETALLIC compounds; DRUG delivery systems; PHOTODYNAMIC therapy; OPTICAL properties of condensed matter
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 26, p8378
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201301348