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- Title
Cardioprotective effect of ethanolic extract of Urtica parviflora Roxb. against isoproterenol induced myocardial infarction in rats.
- Authors
Nishith Ranjan Barman; Nandy, Subhangkar; Datta, Rana; Prasanna Kumar Kar
- Abstract
Objective: The objective of this study is to evaluate the effect of ethanolic extract of Urtica parvilora Roxb. in isoproterenol (ISO) induced myocardial infarction (MI) in rats. Materials and Methods: U. parvilora Roxb. (350 mg/kg and 500 mg/kg, p.o) was administered for 15 days in rats. MI was induced with a single dose of ISO (200 mg/ kg, s.c.) on the 14th and 15th day. At the end of the experimental period (i.e., on the day 16), serum and heart tissues were collected and total cholesterol (TC), high density lipoprotein, triglyceride and malondialdehyde, superoxide dismutase, catalase (CAT), reduced glutathione (GSH) and body weight were determined. Results: Administration of ISO in control rats showed a significant (P < 0.001) increase serum cholesterol alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and low density lipoprotein (LDL). There was a significant increase (P < 0.01) in the levels of heart tissues as compared with respective control groups. Rats treated with U. parvilora significantly (P < 0.01) decreased ALT, AST, ALP, LDL and TC. Moreover, there was an increased CAT and GSH levels in rat treated with U. parvilora Roxb. as compared with the control group. Conclusion: U. parvilora (350 and 500 mg/kg p.o.) is effective in controlling serum LDL levels and reduced cardiac complication in experimentally induced MI in rats.
- Subjects
PLANT extracts; ANIMAL models of myocardial infarction; NETTLES; ISOPROTERENOL; CHOLESTEROL; HIGH density lipoproteins; MALONDIALDEHYDE; SUPEROXIDE dismutase
- Publication
Indian Journal of Pharmacology, 2013, Vol 45, Issue 5, p513
- ISSN
0253-7613
- Publication type
Article
- DOI
10.4103/0253-7613.117782