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- Title
Long-term effects of octreotide therapy on in-stent restenosis.
- Authors
Kursaklioglu, S. Hurkan; Iyisoy, Atila; Amasyali, Basri; Barcin, Cem; Kose, Sedat; Celik, Turgay; Kilic, Ayhan; Ozturk, Cengiz; Demirtas, Ertan
- Abstract
The purpose of this study was to assess the long-term effects of octreotide therapy on in-stent restenosis at 6-month follow-up coronary angiography and the clinical events after stenting. A randomized, double-blind, placebo-controlled trial was conducted to assess the effects of octreotide on restenosis after stenting. The patients (n = 148) received either subcutaneous octreotide or placebo 1 h before the stenting procedure and then every 8 h for 3 weeks. Percent diameter stenosis was interpreted before and after stenting, and on a 6-month follow-up coronary angiogram by quantitative coronary angiography. The mean percent diameter stenosis of the octreotide group was significantly lower than that of the placebo group on the 6-month follow-up coronary angiograms (18.8% ± 14.2% vs 35.0% ± 19.2%, respectively; P = 0.001). The restenosis rate of the octreotide group was statistically lower than that of the placebo group (11.8% vs 26.4%, respectively; P ≪ 0.05). With regard to major cardiovascular events, there was no significant difference between the octreotide and placebo groups. The administration of octreotide for treatment of in-stent restenosis results in a relatively low long-term angiographic restenosis rate and no significant acute effects on cardiovascular clinical events.
- Subjects
OCTREOTIDE acetate; CORONARY restenosis; ANGIOGRAPHY; MEDICAL radiography; RADIOSCOPIC diagnosis; THERAPEUTICS
- Publication
Heart & Vessels, 2003, Vol 18, Issue 3, p130
- ISSN
0910-8327
- Publication type
Article
- DOI
10.1007/s00380-003-0702-3